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D-Mannose is a simple sugar that occurs naturally in some plants, including cranberries. Although small amounts of D-Mannose are metabolized by the human body, much of it is rapidly excreted in the urine. In the bladder, D-Mannose can adhere to undesirable foreign particles, preventing them from sticking to the lining of the bladder.* These particles can then be flushed away during urination. Because insubstantial amounts of D-Mannose are used by the body, it does not interfere with blood sugar regulation.